Subchronic toxicity study of fixed dose combination of ceftriaxone-vancomycin in swiss albino mice

Antibiotics are highly successful in controlling bacterial infection but they have many toxic effects, sometimes very fatal. Aim of the present study was to evaluate subchronic toxicity of fixed dose combination of ceftriaxone-vancomycin in mice. Male and female mice were divided into four groups depending on dose of ceftraixone-vancomycin (0, 10, 100 and 500 mg/kg i.m.). Hematological, biochemical parameters were studied along with histological examination. No significant alteration in hematological and biochemical parameters (SGOT, SGPT, BUN, sugar) were observed in all the group as compared to respective controls, indicating non toxic nature of fixed dose combination of ceftriaxone-vancomycin, which was further confirmed histologically as no structural alteration were observed in liver, kidney, stomach and gonads. In conclusion, sub chronic dose of fixed dose combination of ceftriaxone-vancomycin does not have any toxic effect, especially on liver and kidneys.